Too much methylfolate reddit The MTHFR protocol above is intended to use that incremental approach. I’ll try not to get into a big rant here on that and get to the point. Curious who else has tried it. I felt great the first week but after that I've been in the worst depression ever. If the methylfolate affected your mood greatly, then do not try methyls again until you speak to your practitioner. Instead, consider the added choline from the protocol, which makes use of the alternate remethylation pathway in the methionine cycle I'd lose the mixed one and just take the individual methylfolate and B12 so you can dial it in. I asked how long it will take to drop my level back to normal but he had no answer. If someone can’t process much folic acid, they need other forms of folate. L-methylfolate allows us to synthesize neurotransmitters. Also super evangelical about its efficacy. I'm surprised then you don't mention a methyl B12, given mega dose would exacerbate such issues too. If not eaten from natural sources, the methyl folate can be taken to supplement the slower reactions. Iron utilization. I've found I shouldn't need more than 800 ug of it daily, otherwise I'm either low on glycine or have been taking too much and need to keep a day off. The issue is methylfolate can cause more harm than good if not started Taking too much methylfolate can cause side effects, such as severe anxiety, nausea, insomnia, migraines, irritability, achy joints, headaches, and more. Be careful of too much folinic acid. Having too much dopamine — or too much dopamine concentrated in some parts of the brain and not enough in other parts — is linked to being more competitive, aggressive and having poor impulse control. Methylfolate is short for 5-methyltetrahydrofolate, abbreviated MTHF. Back in the day they used this form of folate to increase histamine levels and still feel weird about it since it also makes more SAM-e Even 100 mcg is too much! Yeah, I could take only methylfolate, but my research indicates it needs to be balanced with other B vitamins. ) Undermethylators with anxiety or Is it better to take folic acid or methylfolate? Methylfolate is supposed to have better bioavailability but if no one works for you give a try to the Trimethylglycine (TMG Those who have MTHFR mutations (especially the C677T MTHFR mutation) learn that methylfolate is critical to take – and that folic acid is critical to avoid. One gene methyl turns off is the serotonin reuptake gene. B12 uses up Your "bit too much" reaction to Jarrow B-right sounds like a classic MAO A R297R +/+ reaction. Reduced it to 400mcg and felt much better after a couple of days. e. too much neurotransmitters Ken, it’s because neurotransmitters require folate to function. Hey guys, I’m double homozygous for MTHFR C677T. I started trying R5P recently, as I think I have a mutation in the pathway that activates B2. So I was on 5mg daily for 1 month & have not been taking any for a week. A genesite test showed I had one inactive allele that would code for producing L-methylfolate from folate or folic acid. I didn't want to take the prescription folic acid (5 grams) because it felt like too much, so I took 800 mcg for 2-3 months. Heart beating, tightness of chest etc. Some of his articles have been retracted, which is never a good sign. One week was fine, then symptoms of methylfolate side effects occurred. Too much B6 is bad especially - I wouldn't supplement any if I were you. I had pretty bad effects with 800mcg methylfolate. The methyl/folate ratio has a powerful impact on gene expression of reuptake transport proteins (page 13). You could be low, get a lot of iron, and your body will be upset from too much incoming iron and it not being able to properly move it, with things like hepcidin. But actually, slightly too much folate, but not a lot, can also make me feel odd too without drifting me into sleep. Using methylfolate if you are overmethylated (produce too much SAM-e) and thus too much serotonin will have a Methylfolate side effects can occur more common in some people than others. I did not get the jitters when I went slowly. If you choose to try it use a very small amount and slowly increase from there to gauge how it goes. I was also going to question this. Yes too high a dose of methylfolate can cause anxiety, headache, joint/muscle pain, brain fog. You are supposed to avoid all folic acid on methylfolate, by the way, as it blocks uptake. I switched from methylfolate 800mcg to folinic acid 800mcg and ended up with a folate waaay above normal range. If you are going to retry the methyls, go to the dose you had BEFORE you had your symptoms and say on that level much longer or until you speak to your practitioner. I wouldn't trust the test so much, they are too unspecific. In fact, supplementation could even cause problems. or any folate other than in meals. ) I'm very sensitive to too much methylfolate. 1. I have a hard time tolerating methylfolate. Not sure if methylfolate is the culprit, I guess I'm going to stop it for a week and see what happens after reading this post. You are taking way too much in short period of time which might cause issues. It’s as if the body must utilize all of it at once because it is in active form pushing the body to try to do too much at once. My Folic Acid levels were in the 15ug/L+ range. I think I may have a slow acting COMT. Some people here say to start introducing methylfolate very slowly, like nibbling on a methylated B vitamin a few times per week and slowly, I for example take 40. The flipside (too much L-methylfolate) is also a problem, too many methyl groups, too much methionine, overmethylation (anxiety, racing thoughts, hyperactivity, increased risk of cancer, etc). What is L-Methylfolate (5-MTHF)? Why methylfolate and not folate? Overmethylation may be linked to intaking too many methyl donors (i. You mention being vegetarian. In clinical trials of Deplin, which is prescription methylfolate, there were no significant side effects recorded. Choline would reduce need for B12 and methylfolate somewhat, so over time you could reduce those in dose or frequency (e. I feel lucky I actually know about these effects of methylfolate. This article actually says ppl with fast COMT tolerate methyl donors like SAMe well, but I've been wondering how much is too much? I already take methylfolate, methylB12, & Quercitin. Apparently there’s a strong correlation between hepcidin and ferritin levels. That reaction turns the homocysteine into methionine. Never worry about too much b12. After supplements Methylcobalamin and Methylfolate I started to urinate too much. im gonna try 50 mg nicotinic acid as a fix because im sensitive to methyl donnors cause of ComT, so that might be the issue. but i need it regardless of anxiety otherwise fatigue digestive issues allergies and brain fog eat me alive. Testing both B2s is good. I am completely panicking right now due to stumbling upon some comments and going down the Google rabbit hole that this has been way too much and I have done irreversible damage to my child. Here's the thing: the two mutations commonly tested for are only 2 of something like 40 genes suspected to be involved in methylation so they're a horrifically incomplete picture of what may be going on. I'm heterozygous for 677t and started taking methylfolate 2 months ago. Yup, I was. The methyl donor problem is usually one of too much too fast. If you have too little, serotonin will be too high. And often people with MTHFR are low on other cofactors too. In my case, many supplements were "too much" and created anxiety and uncomfortable feelings. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; Get the Reddit app Scan this QR code to download the app now. Recently learned I have a mutated MTHFR gene and for starters WOW. That reaction also turns the methylfolate into tetrahydrofolate. Still couldn't increase my B12 dose, so I figured I was still high. I have followed Dr. This makes SO MUCH SENSE. Then yesterday I heard a JRE podcast about how the US sprays everything with Folic Acid unless it's organic and supposedly 40+% of people can't process it and it's poisoning them. Methylfolate supplements can come with side effects, even if you “have MTHFR. I'm back down to 400mg of methylfolate and am taking niacin to counteract a healthy case of overmethylation. Mild deficiency is almost unnoticeable, but as soon as you do something that puts extra load on those vitamins, you'll notice it. And it has negative effects if you end up with too much. Too much can result in overmethylation symptoms. I wouldn't worry too much about a hetero mutation. So we do have to avoid it. I'm homo C677T and I don't worry about it. My doctor is great but I'm not sure she knows a ton about it. Choline would support the alternate remethylation pathway, so it shouldn't be too much because the remethylation would just get partitioned more favorably to this alternate pathway. 2nd question is how does overmethylation cause anger, irritability, and sometimes intense internal rage? I notice myself sometimes over reacting when over methylated. Get app Get the Reddit app Log In Log in to Reddit. So low methylfolate = low serotonin, dopamine, and norepinephrine. So 400mcg is great for 2 days then becomes too much. This came from probably an unreliable kind of "wakadoo" source, so I don't know how much I can believe it. When I started on 1mg methylfolate, Get app Get the Reddit app Log In Log in to Reddit. For example if you take folic acid, it needs to be (which is why too much folic acid can raise cancer risk, but even 10-100x as much methylfolate doesn't) As for your last line, I'd say both. I had so much energy that I couldn’t sleep, but also so much energy that I felt decent anyway. Methylfolate cured my depression and is helping me handle chronic fatigue, but Im still figuring out the dosage. ) So injected folic acid & was back to being fine. After about 4 weeks of riboflavin 3x daily, So I cut back to 400mcg (splitting pills, which I dislike) for a month and had my labs drawn again. Adjust your dose too, it may have been too much or too little and your body is Methylfolate and Methyl-B12, combined, almost entirely suppress my chronic allergies, better than any antihistamine. If not, I can take up to 15mg as well. I get super irritable and anxious, my foot cramps too - but this is WITH taking tons of magnesium alongside methylfolate. Lowering the dose as low as 25mcg for methylfolate is sometimes needed to curb the side effects, and you can slowly add 25mcg a day from Folic acid can be toxic to those of us soul Mthfr, and cause issues for the baby as well. I I don’t know exactly why. Sometimes it feels like I'm taking too much- I can't explain why, it's just an off feeling. Our bodies can not metabolize it, so it causes issues. (Yes, you can have too much serotonin in your body and some people do. My BP seems to be unaffected by this new supplement (consistently 117/77) so I’m keen to keep taking them. I had the exact same experience with methylfolate for the first few days. Your body needs to recalibrate this complex network of chemical interactions to changing methylation, so starting with low doses and working up incrementally over time can prevent/minimize those side effects. If that's the one thing you're missing, yeah, it might make you feel better. I've also been using KSM-66 Ashwaganda to help with the initial side effects of the SSRI that I began not too long ago. Do NOT rely on a Serum Folate to tell you what's going on. I'm a 27-year-old girl, earlier this year I did a blood test and saw I have relatively low folic acid - 3. I've heard that very large (>1mg) amounts of methylfolate can negatively affect people, maybe particularly if they're homozygous MTHFR. I've also been prone, my entire life, to anxiety and depression (also have ADHD and take Ritalin [Methylphenidate for it) - started taking Escitalopram (Cipralex/Lexapro) but didn't notice much benefit from it even after 3 months. B12 deficiancy is strongly correlated with depression, too. Tons of vegetarian stuff is supplemented with folic acid. It positively effects on my mood when I take it on an empty stomach, but I don’t notice it when I take it with food. For me taking Deplin (which is also 15mg methyl folate) for weeks didn't seem to have a positive or negative effect. In medical literature, however, demyelination and other B12 deficiency symptoms have been recorded as people with borderline B12 status who corrected their folate deficiencies found that their low B12 stores were rapidly used. I have other confounding factors like dysfunctional childhood and cocaine addiction but I believe MTHFR is the primary reason I had ADHD. If you have too little reuptake, serotonin will be too high. When I forget to take it, I feel like crap. . So if B12 is very low, too much folate is trapped in the methylfolate form, waiting for a turn. Turns out having too low homocysteine levels is a thing and can host a host of problems. That's why this is called the "methyl trap" hypothesis. You will likely be low in potassium making you feel on edge. I THINK it may have something to do with rapid magnesium depletion. can it also induce overmethylation? should one avoid taking both at the same time, or avoid taking too much methylcobalamin? Can I go from undermethylation to overmethylation with too much methylb12 and methylfolate? Question I learned about methylation a few years back, took the 23andme test like many of you, discussed the results with my doctor, and began supplementing methylb12 (1000-2000mcg) and methylb12 (400-800mcg) daily. I was in the best mood I had been in for years—until it all came crashing down. I have an appointment with an Integrative Medicine specialist in May, but it would be nice to find a supplement before then! I know Niacin is good if you've taken too much methylfolate and want to slow the bad reaction down. But when I added methyl folate, too much made me jittery like I had too much coffee, maybe a little spacey too. Bought 6 bags of oat cereal (Purely Elizabeth, Organic Ancient Grain Granola) and I've felt fine after consuming way too much. Surely you'd still need to supplement with folate/Folinic acid/MethylFolin (not Methylfolate) alongside Choline if you're Methylation is impaired. Mine is a combo of methylfolate, B12, and iron. The study of Methylation and it's effects on the brain is still incomplete, particularlly when it comes to treatment. methylfolate) & can lead to poor concentration, anxiety, panic attacks, & sensitivities to environmental toxins, among other symptoms. “It’s just a supplement, surely it won’t have any side effects/etc” WRONG lol Heard about methyl folate and decided to try it out since it wasn’t too expensive online (Now brand, Amazon). Methylfolate and Methyl-B12, combined, almost entirely suppress my chronic allergies, better than any antihistamine. Cut way back down to under 1mg and see how . If you have too much serotonin reuptake happening, serontonin levels will be low. I don’t know the biochemistry but many in another forum have discussed this problem. Early Feb I switched to methylfolate 1mg daily 11th March switched to 5mg methylfolate daily. I got genetic testing done, found out I have a folate deficiency and an inability to process folic acid, began supplementing with I wouldn't be surprised if I had a folate deficiency as I had some issues with my red blood cells being too large a while ago which can be related - I have since fixed this. If I take too much methylb12 and start going into overdrive, I need methylfolate to stop it, then niacina and glycine work much better to reduce methyl groups and calm me down. Drink lots of water/fluid, that'll help your kidneys eliminate the excess. I was able to increase my B12 to 100mcg. I see that you can take too much folic acid but not sure if taking methylfolate on top of folic acid would put me over a safe limit I took too much methylfolate back in March & was advised to stop taking it for 4 weeks. It's nearly impossible to overdose as it is water soluble. Too much puts you into overmethylation. Even 100mcg is sufficient. Also my homocysteine was BELOW the recommended level somewhere in the 4, forgot the measurement unit. After 3 weeks I suddenly fell into severe deficiency symptoms (weakness, brain fog, fatigue, blurred vision but no bloating. Methylfolate creates a weird agitation in me after a certain dose. I tried taking niacin and that was the only thing being able to calm me down somewhat so that I was acting like a person again for a few hours, and since I want to feel normal as much as possible, I want to know how much niacin would be too much. My mental health has been in a terrible state for a while, maybe longer than i’ve been on Potassium tends to help a lot with methylfolate too, if you haven't tried it already. I'm at the point where my doctor is considering switching me to a formula with folinic acid/hydroxycobalamin. But i would really recommend to check your levels- for vitamin d you should do that anyways once or twice a year, especially when taking a supplement (could be enough, could not be enough but could Late to the party. 000/week. But I just recently read somewhere about how folic acid can attach to the receptors and blocking the spots for methylfolate so that you can't absorb it as well. At first I didn't feel any changes, so I kept taking it. Interesting. Folate or folic acid appears to turn this gene on. Could it be too much dopamine lowering serotonin? Maybe just too much dopamine? Or maybe am i missing a certain nutrient, ie low homocysteine causing a methyl block? Idk So, I take the one a day advanced prenatal which has folic acid, and on the off chance my body isn’t processing it, I’d like to take a straight methylfolate supplement. I wouldn't put too much stock into poorly/un defined medical terms like under- and over-methylation. Or else you'd be relying on Choline pathway If methylfolate is in any way better for you, you have methylation issues, and taking methylfolate is just a tiny part of what you should be doing. I don't think looking at this mutation in isolation yields much insight as to whether you'd benefit from supplementation. Oh for sure. Now Im i see lots of people say they are sensitive to methylfolate and replace it with folinic acid, but methylcobalamin doesn't seem to be mentioned as much in such contexts. Ben Lynch’s protocol, taking many precursors in order to prepare myself to tolerate methylfolate. It doesn't bother me too much that he is a chemical engineer, although it seems a little unusual for someone making "health discoveries," but he seems a little too interested in self-help and self-promotion to I can only guess that methylb12 depletes folate stores, and folinic acid is not absorbing to restore folate levels (maybe even blocking methylfolate?). B6, glucosamine and riboflavin should be unnecessary if you have a balanced diet. One mistake I made with AIP was not getting enough calcium and magnesium which caused poor sleep. I was actually diagnosed with Graves’ disease while supplementing methylfolate and I kind of believe it precipitated my diagnosis. E. WOWnight and day difference compared to where I was before. I am getting much better and controllable improvements if I focus on downstream systems that rely on folate like the choline and creatine synthesis ones. i have the exact same mutations as you and i respond to methylfolate the exact same way too. If I stop for a week then come back, I again get 2 great days, so that means I'm probably overmethylated after 3 days of 400mcg. My psychiatrist gave me 2 Can easily become negative if I take too much, especially with creatine Creatine ~4 g daily, 1 g at a time Speeds up my thinking and gives me mental energy an resilience Gives me physical endurance Used to take less, but 4 g helps keep I see that methylfolate has been offered up as the solution and I hope it's as simple as that for you and that's that. After many years of ED I've came up with the following stack: - Moderate exercise - 2 x 1200mg Citrulline - 2 x 500mg Vitamin C - 2 x 120mg Magnesium Eventually I might take folinic acid instead, but it seems like people eventually run into issues there too. By supplementing for them instead of folate, I realized that I don’t need that much folate. Expand user menu Open settings menu. I'm homozygous for C677T and wanted to know how much should I take to satisfy my body needs. There is a correlation between ADHD and MTHFR mutations, but you need a genetic screen to confirm this (blood work may show elevated levels of homocystine, but not 100% conclusive - testing for folate is a bad indicator, as folate will still be present in blood regardless) not everyone has the mutation and consuming too much L-Methylfolate can I love this website. it causes something called a niacin flush which can be alarming if you're not expecting one. In general, minerals are tricky because there is no substitutes for them and one has to get the right amount (not too much and not too little). It's all about hitting that sweet spot, just enough Yet as far as focusing on tasks or bettering myself has been, not much has changed. You could try 1000mcg but I suspect it won't provide any added benefit. However bear in mind, methylation/MTHFR is a complicated subject that can quickly spiral into a rabbit hole of slippery slopes and 400 mcg methylfolate 500 mcg methylcobalamin I used to take 1,600 mcg methylfolate but found 400 mcg is just as effective. But I’m guessing too much of it without enough amounts of tryptophan or other serotonin precursors may keep the levels in your brain or body down. I'm on a pretty high dose (15) of l-methylfolate. Remember, too, that just because you have a mutation doesn't mean it's active. This is why there has been no upper limit set for b12. g. Anyway, I just realized you did touch on a known methylation phenomenon/issue! When I started taking it all I could think about was preventing miscarriage and it didn't even occur to me that it could hurt him after birth. I haven't tested for MTHFR mutation, but my mum is prescribed methylfolate and I can only assume that she suffers the genetic mutation. And the whole energy metabolism and krebs cycle is so complex, u can't just optimize everyone who has an MTHFR SNP with B9. Chris Masterjohn recommends choline as an alternative methyl donor for that Was trying to find what was the culprit behind the side effect from using methylfolate and in the end I realized half of it from histamine release. Look into Ben Lynch is you haven't already. I stayed for a week on each dose to adjust to it before moving up. General Discussion I (M38) started supplementing Methylcobalamin 1000mcg and methyl folate 1000mcg daily due to B12 deficiency, right after I started I noticed that I urinated too much not like normal, and the amount of urine also is much higher than normal. Meanwhile, some people start right at 15mg, and barely have any side effects at all. I've seen on this site that some doctors are prescribing niacin to I’ve been taking l-methylfolate for about 3 years at 15mg because I was told I have the MTHFR gene. (Since it made no difference in that regard, even after four months). I do, but so has half the population, and they are different. Like I get lumps on my skin from too much folic acid. AIP tends toward deficiency in calcium, magnesium, manganese, molybdenum, lithium, and silicon. Make sure it’s a reputable and safe brand like Now or the other brand options on iHerb. Also some key enzyme have feedback loops, if there is too much of a compound they stop making more. Hey guys, So I took 400mcg of Methylfolate and been experiencing some intense anxiety now a few hours after. It can lead to conditions that include ADHD, binge eating, addiction and gambling. I have tons more energy and focus, and feel much better overall. He had me on 15mg a day and my anxiety increased 5 fold and I started having severe panic attacks thinking it was my Delta-8 THC. Lots of potassium used up in the start-up symptoms for both methylfolate and B12. I switched to methylfolate, which felt gentler to me (folinic acid and adenosyl hydroxo B12 felt like I was on too much). Liver health. Not to mention how often even people who need it expereience issues with too much methylfolate. For example, according to the International Journal of Cancer, 35% of the So many people have the mthfr mutation, but other factors can reduce our natural ability to convert folic acid to l-methylfolate. I can't imagine how many people start a multivitamin with methylfolate in it and after a while develop mental health issues because of it, but aren't able to understand that methylfolate is causing this and they just keep taking it. I was prescribed 15mg for depression, but it makes me very very anxious and I don't want to use methylfolate as a treatment for depression necessarily, just for the MTHFR illness. Do you have MTHFR? 10mg is ridiculously high to start off with, especially without b12. I actually find Folin-ic acid to be much more stable than methyfolate. Yes I've been taking methylfolate since this post, I am homozygous for mutation 667. , every other day) as works best for you. 3 ng/ml. But a lot of people start taking methylfolate only to run out of some other cofactor, like other B vitamins, magnesium, zinc, etc. Make sure the methyl folate you were taking is pure 100% methyl folate without any other ingredients. 1000 µg a day is too much specially that potent form of folate. Just from the 200 micrograms in a multivitamin. Methylfolate is also required for serotonin production somehow. Log In / Sign Up; Advertise on Reddit; it is best to start low and go slow with both L-Methylfolate and Vitamin B12 because too much of a good thing added too quickly can potentially lead to some unwanted emotional changes that could be I am going to keep saying this over and over on this forum because it seriously was a game changer for me. I realised on April 11th so stopped taking methylfolate. Slightly hyper or something. It's almost like someone else wrote this particular article. But it’s a shaky equation. I was recommended to start taking 15mg of l-methylfolate a day. You're psyching yourself up. The MAT downregulation by SAM seems interesting, could very My psychiatrist prescribed me L-methylfolate to help my anti depression meds do their job. It seems it could, as well with serotonin and norepinephrine as SAM-e is required for the synthesis of all of those, and that would get used up pretty quickly for the synthesis of methylfolate or methyl b12. I never noticed any real effects until I switched to a prescription. In this article and video we discuss these side effect, questions that come up when using methylfolate and give some reason why they might occur. ” A nontrivial percentage of the population cannot convert adequate amounts of folate, an important B vitamin, to methylfolate, often due to MTHFR gene variants, and other SNPs that affect the methylation cycle. Was about 1300 ng/L, considered by many doctors as way too high in the unhealthy levels. I was thinking I should catch up on lost B9. Is methylfolate enough to increase methionine levels or should you take anything else too? Question I’m not a good benchmark for you as I’m chronically low. The subject is simply too complex and variable.
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